The road then passes through the village of Binley Woods before becoming more rural in nature, meeting the Fosse Way and crossing the River Avon at Bretford.

The road bypasses Bromham and, leaving behind its former route east-bound through Bedford (which has become the A4280), swings southwards on a new alignment then, via a new bridge over the Great Ouse, merges with the A421 south of Kempston.

The A428 loses its identity here: the route continues as the A421 as it bypasses Bedford, Great Barford and Roxton and goes on to become the dual-carriageway A1 at the Black Cat roundabout.

Heading north, the route leaves the A1 via a grade separated junction just south of St Neots and regains its identity.

[2] On 18 February 2019, Highways England announced final route selection for the new road between Caxton Gibbet and the Black Cat junction (which will cease to be a roundabout and become a three-level GSJ).

In March 2021, Transport Secretary Grant Shapps cancelled a proposed grade-separated dual carriageway between M1 J13 and the A34 near Oxford, citing analysis that showed that its costs would exceed its benefits.