3FO526027329910ENSG00000162390ENSMUSG00000034853Q8WXI4Q8VHQ9NM_147161NM_015547NM_025590NM_001347159NP_056362NP_671517NP_001334088NP_079866Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene.

Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth.

[10] The protein encoded by the ACOT11 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA.

[14] A number of other cellular events are also mediated via acyl-CoAs, for example signal transduction through protein kinase C, inhibition of retinoic acid-induced apoptosis, and involvement in budding and fusion of the endomembrane system.

This mechanism may provide metabolic crosstalk and act to regulate the NADH/NAD+ ratio in order to maintain optimal mitochondrial beta oxidation of fatty acids.