803811489ENSG00000148848ENSMUSG00000054555O43184Q61824NM_021641NM_001288973NM_001288974NM_001288975NM_003474NM_007400NP_001275902NP_001275903NP_001275904NP_003465NP_067673NP_031426Disintegrin and metalloproteinase domain-containing protein 12 (previously Meltrin) is an enzyme that in humans is encoded by the ADAM12 gene.

Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.

Decreased levels of ADAM 12 may be detected in cases of trisomy 21 as early as 8 to 10 weeks gestation.

When nuchal translucency data from approximately 12 weeks gestation was added, this increased the detection rate to 97%.

[9] ADAM12 has also been implicated in the development of pathology in various cancers, hypertension, liver fibrogenesis, and asthma.