875111490ENSG00000143537ENSMUSG00000028041Q13444O88839NM_207194NM_207195NM_207196NM_207197NM_001037722NM_009614NP_997077NP_997078NP_997079NP_997080NP_001032811NP_033744Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.

It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.

Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

[6] ADAM15 has been associated with a number of diseases, most recently Rheumatoid Arthritis where it is required for the activation of the FAK and Src pathways to generate apoptosis resistance in response to apoptotic signalling or cell stress.

[10] ADAM15 has also been shown to have a role in prostate cancer again through increased expression in neoplastic and metastatic tissues compared to normal prostate tissues[9] and also through its modulation of epithelial cell- tumour cell interactions.