9509216725n/aENSMUSG00000036545O95450Q8C9W3NM_021599NM_014244NM_001277305NM_175643NP_055059NP_067610NP_783574A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme[4] that in humans is encoded by the ADAMTS2 gene.

Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues.

Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen.

This clipping step is necessary for collagen molecules to function normally and assemble into fibrils outside cells.

As a result, collagen fibrils are not assembled properly; they appear ribbon-like and disorganized under the microscope.