[5] The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation.

It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body.

It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.

[6] Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria[5] and male infertility.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.