Known proteins in the AGCS family are between 445 and 550 amino acyl residues in length and possess 8 to 12 putative transmembrane α-helical spanners.
These proteins show limited sequence similarity in the APC family (TC# 2.A.3).
[3] High-resolution structures of AgcS from Methanococcus maripaludis were obtained using X-ray crystallography and released in 2019 and show structural homology to other members of the Amino acid-Polyamine-Organocation superfamily of transporters.
These proteins and their descriptions can be found in the Transporter Classification Database.
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