270229665ENSG00000116748ENSMUSG00000070385P23109Q3V1D3NM_001172626NM_000036NM_001033303NP_000027NP_001166097NP_001028475AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene.

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle.

[6] A research report shows that the widely prescribed diabetes medication metformin works on AMP-activated kinase (AMPK) by directly inhibiting AMP deaminase, thereby increasing cellular AMP.

[7] It has been shown that in environments with high potassium concentrations, AMP-deaminase is regulated by ATP and ADP through a “Km-type” mechanism.

In low potassium ion concentrations, a mixed “Km V-type” of the regulation is observed.