ARID1A

Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation.

[8] Two transcript variants encoding different isoforms have been found for this gene.

[15] In breast cancer distant metastases acquire inactivation mutations in ARID1A not seen in the primary tumor, and reduced ARID1A expression confers resistance to different drugs such as trastuzumab and mTOR inhibitors.

[16][17] Lack of this gene/protein seems to protect rats from some types of liver damage.

[20][21]This article incorporates text from the United States National Library of Medicine, which is in the public domain.