1CI646811911ENSG00000128272ENSMUSG00000042406P18848Q06507NM_182810NM_001675NM_001287180NM_009716NP_001666NP_877962NP_001274109NP_033846Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.

These transcription factors share a leucine zipper region that is involved in protein–protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA-binding domain.

[8] Terminal osteoblast differentiation, represented by matrix mineralization, is significantly inhibited by the inactivation of JNK.

[10] ATF4 is also involved in the cannabinoid Δ9-tetrahydrocannabinol–induced apoptosis in cancer cells, by the proapoptotic role of the stress protein p8 via its upregulation of the endoplasmic reticulum stress-related genes ATF4, CHOP, and TRB3.

[13] This article incorporates text from the United States National Library of Medicine, which is in the public domain.