48953313ENSG00000074370ENSMUSG00000020788Q93084Q64518NM_174957NM_174958NM_001163336NM_001163337NM_016745NP_777617NP_777618NP_001156808NP_001156809NP_058025Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.

[5][6] This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells.

Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.

[6] ATP2A3 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.

[7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.