520554670ENSG00000081923ENSMUSG00000039529O43520Q148W0NM_005603NM_001374385NM_001374386NM_001001488NP_005594NP_001001488Probable phospholipid-transporting ATPase IC is an enzyme that in humans is encoded by the ATP8B1 gene.

[8] This gene encodes a member of the P-type cation transport ATPase family and specifically belongs to the subfamily of aminophospholipid-transporting ATPases.

This protein is highly expressed in the small intestine, stomach, pancreas, and prostate and is also found in cholangiocytes and the canalicular membranes of hepatocytes in the liver.

[9][10] The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another.

Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis.