She then featured as the female lead in the 2008 television film Baarish Mein Deewar and the Geo TV series Dil e Nadan, for which she received the Lux Style Award for Best Emerging Talent.

Sheikh was widely praised for her role and received nominations in the Best Actress category at the Lux Style Awards and the Silent River Film Festival.

[2] In an interview given to Jang, Mirza revealed that he had a difficult time convincing Sheikh's father to accept his plans for marriage, and that each meeting with him involved "extensive grilling".

[4] After returning to Pakistan, Sheikh landed a job with Geo Television, where she directed and produced the children talk show, called Bachey Man Ke Sachey.

[8][9] Sheikh played a rickshaw driver who's determined to become the sole breadwinner of the family, in Syed Ali Reza's "Aasmaan Chu Lay".

[11][12] She has done extensive print work for fashion designers, such as Deepak Perwani, Amir Adnan, Nomi Ansari, Niche Lifestyle, Khaadi, Teejays, The Men's Store, Fahad Hussayn, Hang Ten, Maheen Khan, Umbereen Sharmeen, Chinyere, Crossroads and Limited Edition.

[14] She achieved further critical and commercial success for her role of portrayal of Zarnab, in the romance Armaan (2013), which earned her a nomination for the Tarang Housefull Award for Best Actress.

She then went on to play the lead in Iram Parveen Bilal's feature art film Josh: Independence Through Unity, before taking on the role of Natasha in the high-octane action spy thriller, Operation 021, produced by Zeba Bakhtiar and directed by Australian filmmaker, Summer Nicks.