[5] In 2021, De Los Santos pitched for the Altoona Curve and Indianapolis Indians, while missing most of the season with a forearm injury.

[10] On August 12, De Los Santos was placed on the 60-day injured list with a right shoulder latissimus dorsi muscle strain.

[11] In 26 appearances for Pittsburgh in his rookie campaign, De Los Santos registered an 0–3 record and 4.91 ERA with 26 strikeouts and 3 saves in 25+2⁄3 innings pitched.

[14] On November 21, 2023, De Los Santos signed a minor league contract with the New York Yankees organization.

On November 3, 2024, the Yankees added De Los Santos to their 40–man roster to prevent him from reaching minor league free agency.