Hamilton played college baseball for the Washington State Cougars, and was selected by the White Sox in the 11th round of the 2016 MLB draft.

[4][5][6] The Chicago White Sox selected Hamilton in the 11th round of the 2016 Major League Baseball Draft[7] and he signed.

Hamilton made his professional debut with the Arizona League White Sox and after one game was promoted to the Kannapolis Intimidators, where he spent the remainder of the season, going 1–1 with a 3.69 ERA in 31+2⁄3 relief innings pitched.

[19] He spent the remainder of the season with the Triple-A Columbus Clippers, but struggled to an 0–4 record and 6.27 ERA with 24 strikeouts in 18+2⁄3 innings pitched across 15 appearances for the team.

[21] After not making the team in spring training, he was reassigned to the Triple-A Scranton/Wilkes-Barre RailRiders, and agreed to push the opt-out date in his contract to April 5.

[24] Hamilton began the season with a 1.23 ERA in 20 innings pitched, with 30 strikeouts to nine walks, before he went on the injured list due to a strained right groin muscle on May 17.