He has since developed projects for 20th Century Fox, MTV, Warner Brothers, CBS Paramount, and a sitcom entitled Ruminations for The CW.

In August 2008, Karo announced the launch of Ruminations.com, a user-generated humor site that allowed fans to write their own "ruminations" and share them with the community.

On September 17, 2012, the fifteenth anniversary of his first email, Karo ended his Ruminations column after expanding his mailing list from twenty friends to 100,000 worldwide subscribers.

In October 2015, Variety reported that Karo was developing a sitcom for CBS called Squad Goals, executive produced by Ryan Seacrest.

[7] In March 2016, it was reported that Karo was developing an animated series for Comedy Central called Germany, starring Channing Tatum.

[8] In April 2018, Deadline reported that Karo was developing a series for Comedy Central called Living the Dream, starring DJ Dillon Francis.

[9] In December 2018, Variety reported that Karo was developing a series for TBS called Strange Times, with former Blink-182 member Tom DeLonge.