It was also during this time that he became affiliated with Abraham Zacuto and Isaac Abrabanel and was influenced by apocalyptic sentiment popularized after the Spanish inquisition.

This belief became an obsession for Rabbi Abraham would spend countless years searching for proof in the Bible and the Talmud as well as in kabbalistic literature.

He left Portugal and briefly settled in Greece where he wrote the treatise "Mashreh Kitrin" an apocalyptic explanation of the Book of Daniel.

In Jerusalem he wrote "Ma'amar Perek Ḥelek" an explanation of talmudic statements in tractate Sanhedrin relating to messianism.

In 1521, Rabbi Abraham wrote "Iggeret Sod ha-Ge'ullah" in which, he interpreted the Zohar, relating it back to his Messianic beliefs.