It should be avoided near term in a pregnant woman because of the risk of having a premature closure of ductus arteriosus leading to fetal hydrops in the neonate.

Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug.

[5] Aceclofenac works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever.

The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-fold less than naproxen, 4-fold less than diclofenac, and 7-fold less than indomethacin.

), AklofEP (ExtractumPharma), Flemac (Aramis Pharma), Hifenac-P (Intas Pharmaceuticals, India) and Aceflam (Julphar, UAE).