In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes.
[1] These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
[1] microRNA protein-coding host genes[8] Additional examples of acetyltransferases found in nature include:
The predicted three-dimensional structures of histone, choline, and serotonin acetyltransferases are shown below.
[citation needed] As with all enzymes, the structures of acetyltransferases are essential for interactions between them and their substrates; alterations to the structures of these enzymes often result in a loss of enzymatic activity.This enzyme-related article is a stub.