Acquanegra Cremonese (Cremunés: Cuanégra) is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about 70 kilometres (43 mi) southeast of Milan and about 12 kilometres (7 mi) northwest of Cremona.

Acquanegra Cremonese borders the following municipalities: Crotta d'Adda, Grumello Cremonese ed Uniti, Sesto ed Uniti, Spinadesco.

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