Closely related to acylation is formylation, which employ sources of "HCO+ in place of "RCO+".
To do this an acylation reaction is performed, then the carbonyl is removed by Clemmensen reduction or a similar process.
Protein acylation has been observed as a mechanism controlling biological signaling.
[5] Different types of fatty acids engage in global protein acylation.
[7][8] Palmitoleoylation appears to play a significant role in the trafficking, targeting, and function of Wnt proteins.