Adafenoxate is a compound related to centrophenoxine, that has been found to act as a nootropic in rats.

[1] Adafenoxate can be prepared starting with 4-chlorophenoxyacetic acid (pCPA) by converting it to its acid chloride to give 4-chlorophenoxyacetyl chloride (1).

Alternatives, the final step can be accomplished via Fischer–Speier esterification using a Dean-Stark trap.

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