Pirisudanol (Mentis, Menthen, Mentium, Nadex, Nadexen, Nadexon, Pridana, Stivane), also known as pyrisuccideanol, is the succinic acid ester of pyridoxine (a form of vitamin B6) and of deanol (DMAE).

[1] It has been used in Europe in the treatment of mild cognitive impairment as well as fatigue and depression.

[1][2][3][4][5] Pirisudanol is synthesized by the following method:[6][7] Cyclic ketal formation between pyridoxime [33605-94-6] HCl: [58-56-0] (1) and acetone resulted in alpha4,3-O-Isopropylidene Pyridoxine [1136-52-3] (2).

In the other arm of the synthesis succinic anhydride [108-30-5] (3) is then esterified with Deanol [108-01-0] (4) gives Yakton [10549-59-4] (5).

The last step consists of deblocking the protecting group by hydrolysis with 1% formic acid in ethanol to give the product (8).