[6] Soto made his major league debut on May 11, 2019, against the Minnesota Twins, starting the second game of a doubleheader as the 26th man.

[8] With the 2020 Detroit Tigers, he appeared in 27 games, all in relief, compiling a 0–1 record with 4.30 ERA and 29 strikeouts in 23.0 innings pitched.

Despite allowing a two-run homer, he earned the save in a 3–2 opening day win over the Cleveland Indians on April 1.

[12] Soto suffered a fractured finger after getting hit by a line drive on September 17, and was shut down for the remainder of the season.

On January 7, 2023, the Tigers traded Soto and Kody Clemens to the Philadelphia Phillies in exchange for outfielder Matt Vierling, infielder Nick Maton, and catcher Donny Sands.

[17] He made 69 appearances out of the bullpen for the Phillies, compiling a 4.62 ERA with 65 strikeouts and 3 saves across 60+1⁄3 innings pitched.

[19] On July 30, 2024, Soto was traded to the Baltimore Orioles in exchange for minor league pitchers Seth Johnson and Moisés Chace.

He made the Orioles AL Wild Card roster, appearing in one game as the O's lost the series to the Royals 2-0.