In September 2016, he signed a deal worth $5.15 million with the Houston Astros as an international free agent.

[5][6] The Astros added Pérez to their 40-man roster after the season, in order to protect him from the Rule 5 draft.

[8] In 2019, he played for the rookie–level Gulf Coast League Astros, High–A Fayetteville Woodpeckers, and Triple–A Round Rock Express, going 3–1 with a 4.94 ERA and 58 strikeouts over 54+2⁄3 innings.

[10] Pérez made 25 appearances for Cincinnati in 2021, compiling a 1–2 record and 6.38 ERA with 25 strikeouts across 24 innings pitched.

Perez appeared in 65 contests for the Orioles during the 2023 campaign, compiling a 4-2 record and 3.54 ERA with 44 strikeouts and 3 saves across 53+1⁄3 innings of work.