Agio Pnevma (Greek: Άγιο Πνεύμα) is a village and a former community in Serres regional unit of Central Macedonia, Greece located 12 km east of the city of Serres, on the southwestern mountain slopes of Menoikio (altitude 310 m).

Within the village at the hill of St. Constantine the site of a prehistoric settlement is testified, which was abandoned in early antiquity.

After this life continued in the ancient times alongside the present village on the steep hill of "Gradiskos", where were found the ruins of an ancient small town, probably named "Monoikos" and belonged to the region of Odomantice.

In the 3rd AD century, because of the frequent barbaric raids, it was fortified with acropolis, from which some parts of its wall have been preserved to the day.

[7] Of particular interest is also the discovery – a few kilometers northeast – of a marble quarry, which seems to have worked during the imperial period (Ist-3rd century AD).