The line to connect them passed through the centre of the city and was built in 1888, after disputes from residents and a change of design.

On 1 January 1971, the station and most of Greek rail infrastructure were transferred to the Hellenic Railways Organisation S.A., a state-owned corporation.

Freight traffic declined sharply when the state-imposed monopoly of OSE for the transport of agricultural products and fertilisers ended in the early 1990s.

[9][10] With the reconnection of Patras to Athens planned for 2025, Agios Andreas will be a connecting station of the line to Pyrgos.

Service were suspended due to the coronavirus pandemic, becoming the starting point of (what would be) the new Line P1 of the Suburban Railway to the town of Kato Achaia.