In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea.

The systematic name of this enzyme class is agmatine amidinohydrolase.

This enzyme participates in urea cycle and metabolism of amino groups.

7981475986ENSG00000116771ENSMUSG00000040706Q9BSE5A2AS89NM_024758NM_001081408NM_001378862NP_079034NP_001074877NP_001365791In humans, the enzyme is encoded by the AGMAT gene.

[5][6][7][8] As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.