The western terminus of the highway is at an intersection with SR 75 slightly northeast of Albertville.

SR 68 begins at the foothills of the Appalachian Mountains northeast of Albertville.

The highway maintains a generally eastward trajectory between Albertville and Collinsville.

East of an intersection with U.S. Route 11 (US 11), the highway turns to the southeast, continuing on this orientation until it approaches Leesburg.

From there, SR 68 travels to the northeast as it approaches the Georgia state line.