Wentworth's mother, Muffie Cabot (née Mabel Bryant Hobart), was Nancy Reagan's White House social secretary from 1981 to 1983.

[3] Her stepfather, Henry Brandon, was the Washington correspondent for The Sunday Times of London and her maternal grandmother was Janet Elliott Wulsin.

On the program she was known for performing impressions of Cher, Amy Fisher, Hillary Clinton, Princess Diana, Brooke Shields, Lisa Marie Presley, Sharon Stone, and other characters.

Wentworth appeared as a celebrity guest on the July 23, 2017 episode (S2 E07) of The $100,000 Pyramid, opposite Kathy Najimy, helping her contestant partner win the $150,000 grand prize.

Wentworth is married to George Stephanopoulos, ABC News chief anchor, correspondent and former political adviser to the Clinton administration.

They married on November 20, 2001, at the Archdiocesan Cathedral of the Holy Trinity on New York City's Upper East Side in a lengthy service.