The campus is located at 3839 West Camelback Road, northwest of downtown Phoenix, Arizona, United States.

The school predominantly serves students from partner elementary districts Alhambra, Isaac and Phoenix Elementary, although students from across the district come to Alhambra for its Phoenix Union Magnet Program—Medical and Health Studies.

[7] The campus was designed by the noted local architecture firm of Weaver & Drover.

[1] Alhambra's Boys Basketball team won two state titles, in 1974 and 1985, under coach Phil Kemp.

[10] The school's Boys Cross Country team has been placed first in a number of occasions: 2010, 2009, and 2007.