The campus is now part of the Phoenix Biomedical Campus, including three buildings on East Van Buren Street between North 5th and North 7th Streets built in 1911–1912 and designed by Norman Foote Marsh in the Neoclassical style.

[7] When PUHS first opened, it had four classrooms and 90 students,[1] and was located on the second floor of an elementary school.

[9] A "Department for Colored Students" was established at a rear room of PUHS's Commercial Building in 1918, with one teacher.

[8] The school's African American students were then housed in two small cottages that was separated from the PUHS campus by an irrigation ditch.

[1] North High would later reopen in 1983 as the result of a lawsuit in state court.

[8] The school campus sits on a former residential area, bordered in part by two arterial streets, which was a factor in its selection as the site for PUHS.

[8] The school campus consists of nine buildings, of different architectural styles, and includes a stadium with a track and football field.

[18] The high number of students enrolled at the school was seen as a reason behind its dominance.

[18] Media related to Phoenix Union High School at Wikimedia Commons