Aliens: Infestation is a 2011 Metroidvania video game developed by WayForward Technologies and published by Sega for the Nintendo DS handheld console.

Gameplay of Aliens: Infestation is comparable to the Metroid video games, where players are encouraged to search and backtrack for weapons, upgrades, and keys.

[1] To capture the films' slasher appeal, while still keeping the player emotionally invested, the development team created 20 unique characters, with the game's dialogue re-written 20 times, to make sure it offered the biggest 'gut-punch' when one dies.

In conjunction with the game's 'party of four' mechanic, the developers wanted players to grow attached to their favorites, which, in-turn, increased the likelihood of getting one killed.

[1] The gameplay of Aliens: Infestation was inspired by Metroidvania games such as Super Metroid and Castlevania: Symphony of the Night, along with first-person shooters such as Tom Clancy's Rainbow Six Vegas and Call of Duty 4: Modern Warfare.

According to Tierney, the most difficult part of development was the creation of the titular xenomorphs, which were to behave like the creatures in the films but simultaneously function as video game enemies.