Anu has a high-tech glasses which allow her to scan objects; Octavio can browse other people's social media pages and hack into their devices; Fran can freeze enemies using her hoverchair.

[2] New Tales from the Borderlands is set about a year after the events of Borderlands 3, and introduces a cast of new characters, including three playable protagonists: Anuradha “Anu” Dhar (Michelle Rambharose), an altruistic scientist; Octavio Wallace-Dhar (Diego Stredel), Anu's adopted brother who is seeking fame and fortune; and Francine “Fran” Miscowicz (Lucia Frangione), the owner of a frozen yogurt store who uses a hoverchair for mobility.

[3] The player must guide the three protagonists, each with their own hopes and dreams, as they fight against Tediore agents, as well as monsters and criminals that roam the planet.

Weapon salesman Marcus Kincaid (Bruce DuBose) returns as the narrator of the game, while Fiona Dillon (Laura Bailey), the other playable protagonist of Tales, makes a cameo appearance in the ending.

Atlas scientist Anuradha Dhar attempts to present her invention, a non-lethal ray gun utilizing Eridium to mimic Siren powers, to her boss, Rhys Strongfork, but the device is rejected and she is fired from her job.

Meanwhile, on Promethea, Anu's estranged adopted brother, Octavio Wallace-Dhar, also struggles to survive the Tediore invasion alongside his friend, assassination bot L0U13.

On Octavio's suggestion, the trio signs up for the reality game show Sink or Swim to pitch the shard, combined with Anu's ray gun, as an invention, in order to win the prize money and start their own business.

Octavio, Fran and L0U13 manage to break free on their own and reunite with each other, then later find Anu, who had a conversation with the shard's spirit entity while in coma.

Meanwhile, it is revealed that Marcus Kincaid is narrating the story to Fiona Dillon, a con artist and Vault Hunter, who deduces where the Anahatium shard ends up next.

However, the game also features returning characters, including Rhys Strongfork, CEO of Atlas and one of the two protagonists from the original Tales, and his employee Lor from Borderlands 3.