He played college football at the University of Miami and was signed by the Jacksonville Jaguars as an undrafted free agent in 2014.

[1] In track, Hurns ran a career-best time of 11.69 seconds in the 100 meters at the 2006 Broward County Championships, where he placed fourth.

[3] At the 2008 FHSAA 4A Region 4 Meet, he recorded a career-best time of 22.11 seconds in the 200 meters, placing seventh in the prelims.

[12] As a senior, Hurns started 11 of 13 games and led the team with 62 receptions for a school single-season record 1,162 yards (18.7-yard avg.)

Playing against the Philadelphia Eagles, Hurns caught four passes for 110 yards and two touchdowns from quarterback Chad Henne.

[23] On November 29, 2015, Hurns was hospitalized after suffering an injury during Week 11 against the San Diego Chargers by hitting his head after attempting a diving catch.

[27][28] Hurns finished his second professional season with 64 receptions for 1,031 yards and 10 touchdowns in 15 games and starts, which all remain his current career highs.

[33] During a Week 8 36–22 road loss to the Tennessee Titans on Thursday Night Football, Hurns caught seven passes for a season-high 98 yards and a touchdown.

[37] During the season-opening 29–7 road victory over the Houston Texans, Hurns' teammate Allen Robinson was lost for the season due to a torn ACL.

[42][43] Three weeks later on his 26th birthday, Hurns had a season-high seven receptions for 70 yards but left the eventual 20–17 overtime victory over the Los Angeles Chargers with an ankle injury.

[47][48] However, during the AFC Championship Game against the New England Patriots, he recorded six receptions for 80 yards as the Jaguars lost on the road by a score of 24–20.

[54] Hurns was named the starter over Williams in the next game against the New York Giants, where he caught a nine-yard reception in the 20–13 victory.

[56] Hurns' production and effectiveness decreased as he was used very sparingly in the latter half of the season, losing his starting position after the Cowboys traded a 2019 first-round draft choice to the Oakland Raiders in exchange for Amari Cooper on October 22, to take over the number one receiver role and also gave more playing time to rookie Michael Gallup.

However, Hurns left the narrow 24–22 victory in the first quarter after suffering a serious ankle injury from a tackle by safety Bradley McDougald while making a 14-yard catch.

Hurns' left foot was turned 90 degrees outward as he laid on the ground and had to be popped back into place by doctors.

It was later revealed that Hurns suffered a dislocated ankle and a broken fibula, forcing him to miss the rest of the playoffs.