[5] The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.

They activate mitogenic responses and regulate growth and proliferation of many cells.

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines.

This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

[8] A role in regulation of dopaminergic neurotransmission has also been suggested.