The 1999–2000 Alpha Ethniki was the 64th season of the highest football league of Greece.
Olympiacos won their fourth consecutive and 29th Greek title.
AEK Athens qualified through the Cup, the 3rd league UEFA Cup place is decided between the teams within 5 points from 6th to 8th place.
UEFA Cup Play-off Iraklis with two Home-matches, Aris one, Panionios none
Annual awards were announced on 19 December 2000.