It forms part of the northern section of the international boundary between Venezuela and Guyana.

There are reports that the Dutch were in the Amacuro in 1637, with settlements reaching the river in the mid-17th century.

[2] Venezuelan claims dispute the fact, citing the History of the colonies of Essequibo, Demerara and Berbice (1785) stated that "the Netherlands’ control had not extended to the Amacuro or even the Barima".

[4] Many Venezuelan indigenous peoples, some of whom are related to Whitewater residents or persons from other communities in the sub-region, cross the Amacuro River daily in search of food and to seek medical attention.

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