Oruwariye committed to Vanderbilt University early in his senior year before decommitting and following Head Coach James Franklin to Penn State.

[5] In 2016, Oruwariye saw more time en route to Penn State's first Big Ten Championship Game victory.

[7][8] Oruwariye burst onto the national scene in 2017 due to his personal-best four interceptions, good for fourth in the Big Ten.

Oruwariye carried his junior year momentum into his redshirt senior year, starting in each of Penn State's 12 games, picking off three passes, and tallying a career highs in tackles, pass defenses, and forced fumbles.

[12] He received an invite to the Reese's Senior Bowl amidst discussions that he could potentially be a first round pick.

[20] In Week 11 against the Carolina Panthers, Oruwariye recorded his first interception of the season off a pass thrown by P. J. Walker during the 20–0 loss.

In the 2022 season, Oruwariye finished with 44 total tackles (36 solo), three passes defended, and one fumble recovery in 14 games and five starts.

Oruwariye refused to speak to the media after the game concluded, and wore a towel on his head while walking to the locker room.