He played college football for the UCLA Bruins, earning first-team all-conference honors in the Pac-12.

He was a two-time defensive player of the year and received PrepStar All-West honors as a senior.

He was a three star recruit coming out of high school and committed to play college at the University of California, Los Angeles on May 5, 2015.

He faced competition from Trysten Hill and Chauncey Golston for his starting job.

At the conclusion of the NFL preseason, head coach Mike McCarthy officially named Odighizuwa a starting defensive tackle.

Odighizuwa made his first career start and NFL debut in the Cowboys' Week 1 loss to the Tampa Bay Buccaneers.

Odighizuwa recorded his third straight tackle for loss in a Week 5 victory against the New York Giants.

[14] His older brother Owa Odighizuwa played as a defensive end in the NFL.

[4] Odighizuwa's father, Peter, was the perpetrator of the 2002 Appalachian School of Law shooting, in which three were killed and three were wounded.