The earlier issues before the title change featured stories drawn by a number of artists including Jack Kirby, Don Heck and Steve Ditko.

[1] Lee in 2009 described these "short, five-page filler strips that Steve and I did together", originally "placed in any of our comics that had a few extra pages to fill", as "odd fantasy tales that I'd dream up with O. Henry-type [twist] endings".

[4] In numerous interviews Lee has recalled how the title had been slated for cancellation, and so with nothing to lose, publisher Martin Goodman reluctantly agreed to allow him to introduce Spider-Man, a new kind of superhero – one who would be a teenager, but not a sidekick, and one who would have everyman doubts, neuroses and money problems.

[5] However, while this was indeed the final issue, its editorial page anticipated the comic continuing and that "the Spiderman [sic] ... will appear every month in Amazing".

In 2008, an anonymous donor gave the original 24 pages of Ditko art for Amazing Fantasy #15 to the Library of Congress, which included Spider-Man's debut and the stories "The Bell-Ringer", "Man in the Mummy Case", and "There Are Martians Among Us".

In an attempt to fill that gap, Marvel published three Spider-Man flashback stories in Amazing Fantasy #16–18 (Dec. 1995 – March 1996), each written by Kurt Busiek and painted chiefly by Paul Lee.

2) #16–20 (Feb.-June 2006), introduced Death's Head 3.0, a revamp of the Marvel UK character, written by the original version's creator, Simon Furman.