She is a member of Hololive English – Myth (stylized as HoloMyth), alongside Takanashi Kiara (小鳥遊キアラ), Mori Calliope, Ninomae Ina'nis (一伊那尓栖), and Gawr Gura.

[6][7] She shares her last name with Dr. John Watson, Sherlock Holmes' confidant from the series of detective stories written by Arthur Conan Doyle.

[8] Cover Corporation announced auditions for English speakers from April 23 to May 24, 2020, following the global success of its Japanese VTuber lineup.

[11] In October 2021, Hi-Rez Studios partnered with Hololive and release an announcer pack for the multiplayer first-person shooter game Paladins, featuring Amelia Watson's voice, in celebration of her reaching 1.5 million subscribers on YouTube.

[15][16] Amelia Watson appears as a playable character in 2022 roguelike shoot 'em up video game HoloCure – Save the Fans!.