The house was sequestered by Parliament after Oswald's son Nicholas Mosley supported the king in the Civil War, but was returned after payment of a £120 fine.

The house remained in the family until Sir John Mosley inherited it from a cousin in 1779 and preferring to live on his estate in Staffordshire, sold it.

[2] In his book, Lancashire Gleanings (1883), William Axon tells of the "curious Manchester tradition" that the Young Pretender, Charles Edward Stuart, visited the town, in disguise, in 1744 and stayed with Sir Oswald Mosley at Ancoats Hall for several weeks, to assess whether the people of Manchester were "attached to the interests of his family".

Axon was not fully convinced by the story as he could find no other evidence for it other than an account in the Sir Oswald Mosley's Family Memoirs, printed for private circulation.

[1] During the Industrial Revolution at the end of the 18th century Ancoats Hall was bought by one of the new elite – wealthy Manchester merchant, William Rawlinson.