He also inherited the title of Count of Malta and Gozo from his father Manfredi Chiaramonte.
Andrea succeeded Manfredi as the seventh count of Modica, and continued the policy of aversion to the Aragonese of Sicily.
When Martin I became king of Sicily following his marriage to Maria di Sicilia, he then reconquered the island militarily, the Chiaramontes found themselves together with the Alagonas alone to face the Catalan army of Bernat (or Bernardo) Cabrera.
He was sentenced to death for the felony of rebellion, and executed by beheading on 1 June 1392 in Palermo in front of the Steri palace.
[1] With him, the Chiaramonte family diminished as their assets were confiscated and divided between Guglielmo Raimondo II Moncada, the Sidoti and Landolina.