In the Genesis version, the Warner Siblings, Yakko, Wakko, and Dot, decide to open up a hip-pop culture shop in order to become closer to their favorite movie stars.

However, once they collect all the memorabilia, Pinky and the Brain attempt to steal them in order to further their world domination plans.

In the SNES version, the Brain once again has another plan to conquer the world by deciding to steal the script of the new Warner Bros. film while it was under development.

On normal and hard modes, the Game Boy version continues after the player completes the first three levels, goes to Once There Was A Man Named Oscar, and battles Pinky and the Brain.

Characters are defeated from touching harmful enemies or objects, or being captured by the security guard, Ralph.

Throughout the game, there are small robots with white blockheads, red bodies, and yellow appendages who work for Pinky and the Brain.

Reviewing the Genesis version, GamePro assessed that the game successfully appeals to the TV show's preadolescent target audience.

They criticized the limited music and absence of voices, but praised the cartoony and detailed graphics and the way the level design requires the player to make regular use of all three characters.

[6] They gave the Super NES version a negative review, citing overly simplistic and frustrating gameplay, though they did praise the graphics for their large and colorful sprites and background references to the TV show.

[10] Next Generation reviewed the Genesis version of the game, rating it three stars out of five, and stated that "Cutting edge innovation isn't here, but what is here is plenty of fun.