From 1997 to 2000, Lewis served as director of communications and counselor to President Bill Clinton in the White House.

She chaired the U.S. Government Working Group for the Women 2000: Beijing Plus Five Special Session of the General Assembly.

[6] She participated in the 1971 founding meeting of the National Women's Political Caucus in Houston, Texas and was chosen to serve on its operating committee.

She served on the advisory committee for the book Jews and American Politics, published in the fall of 2001, and is a member of the board of the Jewish Women's Archive.

A regular speaker on politics and current events in the United States, Lewis delivered the keynote address to the European Forum in Alpbach, Austria, in 1999 on "Media and Democracy".

She was a member of the U.S. delegations to the Vital Voices "Dawn of a New Millennium" Conference in Reykjavík, Iceland and to the European Preparatory session for the Beijing Plus Five Session in Geneva; led workshops in South Africa in preparation for the first-ever democratic elections in that country, and has participated in training seminars for political leaders in Eastern Europe.

[10] In 2002, Lewis was nominated for an Emmy Award for her work on the script America: A Tribute to Heroes, broadcast on all networks following the September 11 attacks.

In June 2009, Lewis was honored with the inaugural National Jewish Democratic Council's Belle Moskowitz Award in Washington, D.C. President Bill Clinton was the special guest.