[4] Li entered the Lexington Challenger where she defeated Renata Zarazúa, Julia Glushko, Anastasia Nefedova, Jessica Pegula before losing to Asia Muhammad, in straight sets.

[13] Li won her maiden WTA Tour title at the Tenerife Ladies Open, defeating Camila Osorio in the final, in straight sets.

[16] At the 2022 Miami Open, Li reached the third round of a WTA 1000 for the first time defeating third seed Anett Kontaveit,[17][18] before losing to Alison Riske.

[25][26] In June, Li won her first WTA 125 title at the BBVA Open Internacional de Valencia, defeating top seed Viktoriya Tomova in the final.

[27][28] The following month, she reached the quarterfinals in Palermo with wins over third seed Peyton Stearns, where she saved a match point, and Erika Andreeva,[29] before losing to Irina-Camelia Begu.

[30] At the Mérida Open she defeated eighth seed Nuria Parrizas-Diaz,[31] Antonia Ružić[32] Jil Teichmann[33][34] and Polina Kudermetova[35] to reach the final, which she lost to Zeynep Sönmez in straight sets.

[36] Li reached the final at the Singapore Open with wins over Daria Saville,[37] lucky loser Maria Timofeeva,[38] wildcard entrant Kimberly Birrell[39] and top seed Anna Kalinskaya.

[42] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup, and Olympic Games are included in win–loss records.