Iga Świątek defeated Naomi Osaka in the final, 6–4, 6–0 to win the women's singles tennis title at the 2022 Miami Open.

She became the fourth woman in history (after Steffi Graf, Kim Clijsters, and Victoria Azarenka) to complete the Sunshine Double in singles, having won Indian Wells two weeks earlier.

77, Osaka was the lowest-ranked Miami Open finalist in history, surpassing Clijsters' 2005 achievement as the then-world No.

[3] Ashleigh Barty was the two-time reigning champion,[4] but withdrew from the tournament citing health issues.

1 after winning her second round match, making her the 28th player and the first Pole to hold the top singles position since the computer rankings began in 1975.

† The player retired from professional tennis and requested to be removed from the WTA rankings at the end of the tournament.