The Annunziata Polyptych is a painting cycle started by Filippino Lippi and finished by Pietro Perugino, whose central panel is now divided between the Galleria dell'Accademia (Deposition from the Cross) and the Basilica dell'Annunziata, both in Florence, Italy.

The polyptych had other six panels, which are housed in the Lindenau-Museum of Altenburg, the Metropolitan Museum of New York City, the Galleria Nazionale d'Arte Antica in Rome and in a private collection in South Africa.

The work was originally commissioned to Filippino Lippi for the high altar of the Annunziata Basilica in Florence.

Lippi had already ceded the same commission to Leonardo da Vinci, who had executed a cartoon with St. Anne, the Virgin and the Child, before abandoning the work when he followed Cesare Borgia (1502).

The person praying at the foot of the cross is Mary Magdalene, regarding reverently the feet that she had so recently washed and anointed.