The Madonna of Loreto is a c.1507 oil on panel painting by Perugino, now in the National Gallery, London, which bought it in 1879.

It shows the Madonna and Child flanked by Jerome (left) and Francis of Assisi (right).

Two angels hover over Mary's head holding a crown.

The painting was commissioned by Giovanni di Matteo Schiavone (died 7 June 1507) for a planned chapel at Santa Maria dei Servi church in Perugia.

It probably originally had a predella of three small panels (Annunciation, Adoration of the Shepherds and Baptism of Christ), now in the Galleria Nazionale dell'Umbria.